Disseminated intravascular coagulation

@article{Levi2007DisseminatedIC,
  title={Disseminated intravascular coagulation},
  author={Marcel Levi},
  journal={Critical Care Medicine},
  year={2007},
  volume={35},
  pages={2191-2195}
}
  • M. Levi
  • Published 2007
  • Medicine
  • Critical Care Medicine
Objective:To review the current knowledge on the clinical manifestation, pathogenesis, diagnosis, and management of disseminated intravascular coagulation (DIC). Data Source:Selected articles from the MEDLINE database. Data Synthesis:DIC may complicate a variety of disorders and can cause significant morbidity (in particular related to organ dysfunction and bleeding) and may contribute to mortality. The pathogenesis of DIC is based on tissue factor–mediated initiation of systemic coagulation… Expand
Treatment of Disseminated Intravascular Coagulation (DIC)
TLDR
There is not a single test, however, that is sufficiently accurate to establish or reject a diagnosis of DIC, so a combination of widely available tests may be helpful in making the diagnosis and can be helpful to guide in the selection of D IC patients that require specific, often expensive, interventions in the coagulation system. Expand
Laboratory Management of DIC
TLDR
This chapter discusses the laboratory management of disseminated intravascular coagulopathy (DIC), which is characterized by the consumption and degradation of coagulation factors as a consequence of the unregulated and excessive generation of thrombin. Expand
COVID-19 PNEUMONIA: THE POINT OF VIEW OF VASCULAR SPECIALIST
TLDR
Potentially involved factors in the impairment of coagulation caused by viral infection include the dysregulated inflammatory response, platelet and endothelial dysfunction with impaired fibrinolysis, and the use of low molecular weight heparin could prevent thromboembolic complications in COVID-19 pneumopathy. Expand
Incidence of disseminated intravascular coagulation in critically ill cancer patients
TLDR
A low incidence of DIC was found in critically ill cancer patients admitted to the ICU during the period between December 2015 and May 2016 and the potential risk factors for developing DIC upon admission to theICU were evaluated. Expand
Current anticoagulation therapy for sepsis-induced disseminated intravascular coagulation in Japan : results of a multicenter study using administrative data
TLDR
It is revealed that protease inhibitors were most frequently used in DIC anticoagulation therapy in ICUs in Japan, and unfractionated heparin was the only therapy to have a significant adverse effect on mortality. Expand
Disseminated Intravascular Coagulation in Cardiac Surgery
Disseminated intravascular coagulation (DIC) is a complex thrombohemorrhagic disease, secondary to an underlying clinical disease,1 producing both thrombosis and hemorrhage. It is initiated by aExpand
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia.
TLDR
It is not possible to determine whether human activated protein C, recombinant human soluble thrombomodulin, tranexamic acid and dermatan sulphate are effective or harmful for patients presenting with DIC related to acute or chronic leukemia. Expand
Thrombocytopenia-Associated Multiple Organ Failure Syndrome
TLDR
The biologic and molecular understanding of the pathophysiologic processes governing DIC, TTP and HUS have significantly expanded and allow better laboratory delineation among these three entities. Expand
Nonovert disseminated intravascular coagulation (DIC) in pregnancy: a new scoring system for the identification of patients at risk for obstetrical hemorrhage requiring blood transfusion.
  • Ali Alhousseini, R. Romero, +9 authors O. Erez
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2020
TLDR
A pregnancy-specific nonovert DIC score adjusted for the physiologic changes in the hemostatic system during gestation can be a useful tool for the identification of patients at risk for obstetrical hemorrhage requiring blood products transfusion. Expand
Disseminated intravascular coagulopathy in the first 24 hours after trauma: the association between ISTH score and anatomopathologic evidence.
TLDR
Considering pathologic findings as the gold standard diagnosis, then DIC is exceptionally uncommon and the ISTH score should not be used for trauma. Expand
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References

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Disseminated intravascular coagulation.
TLDR
This chapter briefly reviews the clinical setting, incidence, and relevance of DIC and current insights into the pathogenesis of D IC and discusses the available knowledge on the clinical management of patients with this syndrome. Expand
Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation
TLDR
Restoration of disrupted physiologic anticoagulant pathways in disseminated intravascular coagulating is not only a logical point of impact in patients with sepsis and an activated coagulation system, but also is associated with an improved outcome in experimental and (initial) clinical studies. Expand
Disseminated intravascular coagulation in trauma patients.
  • S. Gando
  • Medicine
  • Seminars in thrombosis and hemostasis
  • 2001
TLDR
Sustained systemic inflammatory response characterized by neutrophil activation and endothelial damage plays a pivotal role in the development of multiple organ dysfunction syndrome (MODS) in posttrauma DIC patients. Expand
Pathology of disseminated intravascular coagulation (DIC). Analysis of 26 cases.
TLDR
The location and severity of fibrin thrombi, the types of vessels affected, skin biopsy as a diagnostic procedure, unusual syndromes of disseminated intravascular coagulation, consequences of major vessel thromboses, and complications intrinsic to the disorder or those induced inadvertently by therapy are presented. Expand
Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation*
TLDR
A diagnosis of DIC based on a simple scoring system, using widely available routine coagulation tests, is sufficiently accurate to make or reject a diagnosis ofDIC in intensive care patients with a clinical suspicion of this condition. Expand
The cytokine‐mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia
TLDR
The mechanisms that lead to activation of coagulation, potentiated by the simultaneous depression of physiological inhibitory systems and to impaired function of the fibrinolytic system, are outlined in this review and the mediatory role of various cytokines in the derangement ofCoagulation is discussed. Expand
Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation 1
  • J. Dhainaut, S. B. Yan, +5 authors M. Levi
  • Medicine
  • Journal of thrombosis and haemostasis : JTH
  • 2004
TLDR
Modified ISTH overt DIC scoring may be useful as an independent assessment for identifying severe sepsis patients at high risk of death with a favorable risk/benefit profile for DrotAA treatment. Expand
Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis*
TLDR
The simple evolving DIC score calculated in the first 48 hrs from two readily available global coagulation markers appears to reflect the severity of the underlying disorder. Expand
Coagulation in sepsis: all bugs bite equally
TLDR
It is demonstrated that the vast majority of patients with severe sepsis have increased markers for systemic coagulation activation, decreased physiological anticoagulant proteins and depressed fibrinolysis, and there is no correlation between the type of microorganism that has caused the infection and the presence or severity of the coagulated disorder. Expand
Treatment effects of high‐dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation
TLDR
The adapted ISTH DIC score may identify patients with severe sepsis who potentially benefit from high‐dose AT treatment, and may result in a significant mortality reduction. Expand
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