Disseminated intravascular coagulation

  title={Disseminated intravascular coagulation},
  author={Marcel Levi},
  journal={Critical Care Medicine},
  • M. Levi
  • Published 1 September 2007
  • Medicine
  • Critical Care Medicine
Objective:To review the current knowledge on the clinical manifestation, pathogenesis, diagnosis, and management of disseminated intravascular coagulation (DIC). Data Source:Selected articles from the MEDLINE database. Data Synthesis:DIC may complicate a variety of disorders and can cause significant morbidity (in particular related to organ dysfunction and bleeding) and may contribute to mortality. The pathogenesis of DIC is based on tissue factor–mediated initiation of systemic coagulation… 

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High-dose antithrombin III therapy had no effect on 28-day all-cause mortality in adult patients with severe sepsis and septic shock when administered within 6 hours after the onset and was associated with an increased risk of hemorrhage when administered with heparin.

Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis*

The simple evolving DIC score calculated in the first 48 hrs from two readily available global coagulation markers appears to reflect the severity of the underlying disorder.

Cancer and DIC.

Disseminated intravascular coagulation in trauma patients.

  • S. Gando
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  • 2001
Sustained systemic inflammatory response characterized by neutrophil activation and endothelial damage plays a pivotal role in the development of multiple organ dysfunction syndrome (MODS) in posttrauma DIC patients.

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Sepsis-induced thrombin generation in severely septic patients is reset by rhAPC within the first 8 h of infusion without influencing parameters of fibrinolysis and inflammation.

Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: A multicenter, randomized, placebo-controlled, single-blind, dose escalation study

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Distribution of microthrombi in 37 autopsy cases of untreated disseminated intravascular coagulation (DIC) was studied histologically and suggested that these patterns indicated the course of DIC and the function of Kupffer's cells in the liver, whose role in the course was evaluated.

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