Disseminated intravascular coagulation

@article{Levi2007DisseminatedIC,
  title={Disseminated intravascular coagulation},
  author={Marcel Levi},
  journal={Critical Care Medicine},
  year={2007},
  volume={35},
  pages={2191-2195}
}
  • M. Levi
  • Published 1 September 2007
  • Medicine
  • Critical Care Medicine
Objective:To review the current knowledge on the clinical manifestation, pathogenesis, diagnosis, and management of disseminated intravascular coagulation (DIC). Data Source:Selected articles from the MEDLINE database. Data Synthesis:DIC may complicate a variety of disorders and can cause significant morbidity (in particular related to organ dysfunction and bleeding) and may contribute to mortality. The pathogenesis of DIC is based on tissue factor–mediated initiation of systemic coagulation… 

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References

SHOWING 1-10 OF 51 REFERENCES

Drug therapy: Prevention and treatment of major blood loss

From the Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and the Department of Medicine and Medical Specialties, University of Milan; the Istituto di Ricovero e Cura a Carattere Scientifico,

High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial

High-dose antithrombin III therapy had no effect on 28-day all-cause mortality in adult patients with severe sepsis and septic shock when administered within 6 hours after the onset and was associated with an increased risk of hemorrhage when administered with heparin.

Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis*

The simple evolving DIC score calculated in the first 48 hrs from two readily available global coagulation markers appears to reflect the severity of the underlying disorder.

Cancer and DIC.

Disseminated intravascular coagulation in trauma patients.

  • S. Gando
  • Medicine, Biology
    Seminars in thrombosis and hemostasis
  • 2001
Sustained systemic inflammatory response characterized by neutrophil activation and endothelial damage plays a pivotal role in the development of multiple organ dysfunction syndrome (MODS) in posttrauma DIC patients.

Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study

Sepsis-induced thrombin generation in severely septic patients is reset by rhAPC within the first 8 h of infusion without influencing parameters of fibrinolysis and inflammation.

Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: A multicenter, randomized, placebo-controlled, single-blind, dose escalation study

This study demonstrates that rTFPI doses of 0.025 and 0.05 mg/kg/hr could be safely administered to severe sepsis patients and biological activity, as detected by a statistically significant reduction in thrombin-antithrombin complexes and interleukin-6 levels, was noted in the all rT FPI-treated patients compared with those receiving placebo.

The use of soluble fibrin in evaluating the acute and chronic hypercoagulable state.

  • C. Dempfle
  • Biology, Medicine
    Thrombosis and haemostasis
  • 1999
Clinical applications of soluble fibrin assays include diagnosis and treatment monitoring of intravascular coagulation processes and prethrombotic states, monitoring anticoagulant treatment, and biocompatibility investigations.

Distribution patterns of microthrombi in disseminated intravascular coagulation.

Distribution of microthrombi in 37 autopsy cases of untreated disseminated intravascular coagulation (DIC) was studied histologically and suggested that these patterns indicated the course of DIC and the function of Kupffer's cells in the liver, whose role in the course was evaluated.

Prevention and treatment of major blood loss.

The benefits of hemostatic drugs are reviewed and the associated risk of adverse events, particularly thrombotic complications, are considered.
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