Disseminated intravascular coagulation

@article{Gando2016DisseminatedIC,
  title={Disseminated intravascular coagulation},
  author={Satoshi Gando and Marcel Levi and Cheng Hock Toh},
  journal={Nature Reviews Disease Primers},
  year={2016},
  volume={2}
}
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by widespread intravascular activation of coagulation that can be caused by infectious insults (such as sepsis) and non-infectious insults (such as trauma). The main pathophysiological mechanisms of DIC are inflammatory cytokine-initiated activation of tissue factor-dependent coagulation, insufficient control of anticoagulant pathways and plasminogen activator inhibitor 1-mediated suppression of fibrinolysis… Expand
Pathogenesis and diagnosis of disseminated intravascular coagulation
  • M. Levi
  • Medicine
  • International journal of laboratory hematology
  • 2018
TLDR
Some specific clinical situations may elicit coagulation responses that can be distinguished from DIC or may occur in combination with DIC, including dilutional coagulopathy, liver failure‐related coagulations derangement, and thrombotic microangiopathies. Expand
Sepsis and disseminated intravascular coagulation
TLDR
Investigation of the efficacy of recombinantTM and AT in countries other than Japan, as well as the monitoring of medical costs incurred during hospitalization, will help validate the use of TM and AT for treatment of septic DIC. Expand
Disseminated Intravascular Coagulation.
TLDR
A case scenario and a review of the literature related to the pertinent facts concerning DIC are provided, and the massive tissue factor stimulus results in excess intravascular thrombin, which overcomes the anticoagulant systems and leads to thrombosis. Expand
Diagnosis of sepsis‐induced disseminated intravascular coagulation and coagulopathy
TLDR
The strengths and weaknesses of the major criteria including JAAM DIC, ISTH overt‐DIC, sepsis‐induced coagulopathy, and Japanese Society on Thrombosis and Haemostasis‐D IC are introduced. Expand
Recombinant Human Soluble Thrombomodulin in Patients With Sepsis-Associated Coagulopathy: Another Negative Sepsis Trial?
TLDR
The study failed to demonstrate a reduction in the primary end point of 28-day allcause mortality, raising the question of why the study was conducted given prior results with other anticoagulants, and soluble human recombinant thrombomodulin has a different mode of action that offers important theoretical advantages. Expand
Disseminated intravascular coagulation in cardiac arrest and resuscitation
TLDR
The coagulofibrinolytic changes in cardiac arrest and resuscitation meet the definition of DIC proposed by the ISTH, and that DIC is associated with organ dysfunction and poor patient outcomes implies that established DIC should be considered to be one of the main therapeutic targets in post–cardiac arrest syndrome. Expand
How we manage haemostasis during sepsis
TLDR
Scoring systems can be used to help identify patients at risk of DIC and aid in confirming a diagnosis of Dic utilising routine laboratory parameters, and in severe cases, associated with hypofibrinogenaemia, with overactivation of the fibrinolytic path. Expand
Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis.
TLDR
The antithrombotic property of embelin is demonstrated and the potency of the treatment or prevention of syndromes combining inflammation and thrombosis, e.g. sepsis-induced DIC is proposed. Expand
Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment.
TLDR
The mechanisms underlying thrombocytopenia in sepsis have yet to be fully understood but likely involves decreased platelet production, platelet sequestration and increased consumption. Expand
Recent advances in pathophysiology of disseminated intravascular coagulation: the role of circulating histones and neutrophil extracellular traps
TLDR
Significant recent advances in understanding of DIC pathophysiology are focused on circulating histones and neutrophil extracellular traps, which have a strong potential to be novel biomarkers and therapeutic targets in DIC. Expand
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TLDR
Experimental and clinical evidence now indicate that the initiation of coagulation in DIC is caused by tissue factor expression, which in combination with downregulated physiological anticoagulant pathways and impaired fibrinolysis leads to widespread fibrin deposition. Expand
Current consideration and management of disseminated intravascular coagulation.
  • C. Toh, Y. Alhamdi
  • Medicine
  • Hematology. American Society of Hematology. Education Program
  • 2013
TLDR
This article refreshes the conceptual understanding of DIC pathogenesis and draws in recent advances in the cycle of cell death caused by extracellular nuclear proteins to enable a more personalized and evidence-based approach to be delivered to the patient with DIC. Expand
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The intricate relationship between inflammation and coagulation may not only be relevant for vascular atherothrombotic disease in general but has in certain clinical settings considerable consequences, for example in the pathogenesis of microvascular failure and subsequent multiple organ failure, as a result of severe infection and the associated systemic inflammatory response. Expand
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Information is suggested that COT/ACOTS is not a new concept but a disease entity similar to or the same as DIC with the fibrinolytic phenotype, which is probably incorrect. Expand
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TLDR
Heparin may be an effective anticoagulant approach and alternative strategies comprise restoration of physiological anticoAGulant pathways. Expand
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TLDR
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Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy
TLDR
Endothelial-derived microparticles are relevant biomarkers of septic shock-induced DIC and could be used to evaluate early vascular injury. Expand
Trauma, Shock, and Disseminated Intravascular Coagulation: Lessons from the Classical Literature
TLDR
Treatments of DIC with the fibrinolytic phenotype involve the surgical repair of the trauma, improvement of shock, and the rapid and sufficient replacement of platelet concentrate, fresh frozen plasma, and depleted coagulation factors. Expand
Classifying types of disseminated intravascular coagulation: clinical and animal models
TLDR
In animal DIC models, lipopolysaccharide (LPS)- induced models are similar to suppressed-fibrinolytic-type DIC, whereas tissue factor (TF)-induced models areSimilar to enhanced fibrino-lytic/balanced fibralelytic DIC. Expand
Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation
TLDR
Patients who develop DIC with the fibrinolytic phenotype during the early stage of trauma exhibit consumption coagulopathy associated with increased fibrin(ogen)olysis and lower levels of antithrombin. Expand
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