Disseminated intravascular coagulation: What's new?

  title={Disseminated intravascular coagulation: What's new?},
  author={Marcel M. Levi},
  journal={Critical care clinics},
  volume={21 3},
Disseminated intravascular coagulation (DIC) is a syndrome characterized by a systemic activation of coagulation leading to the intravascular deposition of fibrin in the (micro) vasculature and the simultaneous consumption of coagulation factors and platelets. The occurrence of microvascular thrombosis as a consequence of DIC is underscored by pathological, experimental and clinical findings, demonstrating a link between DIC and organ dysfunction. Pathogenetic pathways that play a role in the… CONTINUE READING


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