The autopsy findings of two cases of disseminated histoplasmosis capsulatum are reported here. The pathologic changes involved multiple organs, such as lungs, liver, spleen, kidneys, thymus, and deep and superficial lymph nodes. The main pathologic features were caseous necrosis and macrophage infiltration, which engulfed numerous histoplasma in yeast form. In the first case, the colon and skin were also attacked by histoplasma capsuli, as was the head of pancreas in the second case. Acute regression of the thymus was found in both cases.