Disseminated encephalomyelitis and multiple sclerosis: two different diseases – a critical review
@article{Poser2007DisseminatedEA, title={Disseminated encephalomyelitis and multiple sclerosis: two different diseases – a critical review}, author={Charles M. Poser and Vesna V. Brinar}, journal={Acta Neurologica Scandinavica}, year={2007}, volume={116} }
The practice of initiating immunomodulatory treatment immediately after a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) emphasizes the need to distinguish between disseminated encephalomyelitis (DEM) and MS. Their clinical, genetic, imaging, and histopathological characteristics establish that they are distinct disease entities. Acute and recurrent DEM are more common in children, but also occur in adults. DEM is polysymptomatic and includes signs and symptoms rarely…
36 Citations
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The main features of ADEM are described, focusing in particular particular on the factors that influence its outcome and can guide the process of differential diagnosis.
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Consistent and unique MRS changes in metabolite ratios between the acute and chronic presentations of the disease were found and might assist in the early diagnosis of ADEM.
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Clinical and paraclinical characteristics of acute disseminated encephalomyelitis in adults, with special emphasis on diagnostic imaging are summarized.
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