Disseminated and circulating tumor cells: Role in effective cancer management.


Dissemination of tumor cells from primary tumors in the circulatory system is an early event in carcinogenesis. The presence of these single disseminated tumor cells (DTC) in peripheral blood, bone marrow and distant organs is the rationale for adjuvant systemic treatment. Detection of DTC in bone marrow aspirates from breast cancer patients and other solid… (More)
DOI: 10.1016/j.critrevonc.2010.04.008


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