Disseminated adenovirus disease in immunocompromised and immunocompetent children.

@article{Muoz1998DisseminatedAD,
  title={Disseminated adenovirus disease in immunocompromised and immunocompetent children.},
  author={Flor M. Mu{\~n}oz and Pedro A. Piedra and Gail J. Demmler},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1998},
  volume={27 5},
  pages={
          1194-200
        }
}
  • F. Muñoz, P. Piedra, G. Demmler
  • Published 1 November 1998
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
A retrospective review of adenovirus infections at Texas Children's Hospital during 1990-1996 was performed to evaluate the epidemiology, clinical course, management, and outcome of disseminated adenovirus disease (DAD) in children. DAD with multiorgan involvement occurred in 11 (2.5%) of 440 adenovirus-infected patients. Six (54%) of the 11 were immunocompromised and 5 (45%) were immunocompetent. Mortality was 83% among the immunodeficient, 60% in the immunocompetent, and 73% overall. Two (28… 
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TLDR
Although intravenous ribavirin was not effective for all children with severe adenovirus disease in this series or in the literature, therapy is unlikely to be of benefit if begun late in the course of the infection, and the availability of newer rapid diagnostic techniques, such as polymerase chain reaction, may make earlier, more effective treatment of adenvirus infection possible.
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By recognizing that children with adenoviral infections may present with prolonged high fever, leuokocytosis, and elevated C-reactive protein levels, mimicking symptoms of bacterial infections, clinicians will be able to avoid the unnecessary prescription of antibiotics to these patients.
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A previously healthy pubertal girl who presented in severe hypotensive shock and who subsequently had adenovirus DNA detected from the cerebrospinal fluid and no other etiology identified is presented.
Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004–2005
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This adenovirus outbreak, from late autumn to winter, was predominately caused by Adenovirus type 3, and patients with this genotype were significantly older, had a higher incidence of cough and family transmission, and had higher CRP levels than those with other genotypes.
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