Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

@article{Gmez1991DissectionOT,
  title={Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases},
  author={N{\'e}stor G{\'o}mez and Philip S. Cohen},
  journal={Nature},
  year={1991},
  volume={353},
  pages={170-173}
}
MITOGEN activated protein (MAP) kinases (MAPKs) are a family of protein-serine/threonine kinases activated as an early intracellular response to a variety of hormones and growth factors1–4. They are unique in requiring both serine/threonine and tyrosine phosphorylation to become active5 and are the only examples of protein-serine/threonine kinases activated by tyrosine phosphorylation. Nerve growth factor (NGF) promotes differentiation of phaeochromocytoma (PC12) cells, which respond by… CONTINUE READING

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