Dissection of the mitotic and nuclear functions of Chromator, a nuclear-derived spindle matrix component in Drosophila

Abstract

To study the mitotic function of the spindle matrix complex protein, Chromator, we used two new loss-of-function alleles in the Chromator gene, Chro 71 and Chro 612 . We show that neuroblasts from transheterozygous Chro 71 /Chro 612 brains display severely disrupted spindle morphology and chromosome segregation defects. The microtubule spindles at metaphase… (More)

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