Dissection of the XChk1 signaling pathway in Xenopus laevis embryos.

  title={Dissection of the XChk1 signaling pathway in Xenopus laevis embryos.},
  author={Nicholas Chris Kappas and Pamela Savage and Katherine C. Chen and Anthony Walls and Jill C. Sible},
  journal={Molecular biology of the cell},
  volume={11 9},
Checkpoint pathways inhibit cyclin-dependent kinases (Cdks) to arrest cell cycles when DNA is damaged or unreplicated. Early embryonic cell cycles of Xenopus laevis lack these checkpoints. Completion of 12 divisions marks the midblastula transition (MBT), when the cell cycle lengthens, acquiring gap phases and checkpoints of a somatic cell cycle. Although Xenopus embryos lack checkpoints prior to the MBT, checkpoints are observed in cell-free egg extracts supplemented with sperm nuclei. These… CONTINUE READING

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