Dissection of the Molecular Basis of pp60v-src Induced Gating of Connexin 43 Gap Junction Channels

@article{Zhou1999DissectionOT,
  title={Dissection of the Molecular Basis of pp60v-src Induced Gating of Connexin  43 Gap Junction Channels },
  author={Lan Zhou and Eileen M. Kasperek and Bruce J Nicholson},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={144},
  pages={1033 - 1045}
}
Suppression of gap-junctional communication by various protein kinases, growth factors, and oncogenes frequently correlates with enhanced mitogenesis. The oncogene v-src appears to cause acute closure of gap junction channels. Tyr265 in the COOH-terminal tail of connexin 43 (Cx43) has been implicated as a potential target of v-src, although v-src action has also been associated with changes in serine phosphorylation. We have investigated the mechanism of this acute regulation through… CONTINUE READING
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