Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.

@article{Mahajan2007DissectionOP,
  title={Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.},
  author={Anjali K. Mahajan and Yi Fang Guo and Chunhua Yuan and Christopher Weghorst and Ming-Daw Tsai and Junan Li},
  journal={Journal of molecular biology},
  year={2007},
  volume={373 4},
  pages={990-1005}
}
Protein-protein interactions usually involve a large number of residues; thus it is difficult to elucidate functional and structural roles of specific residues located in the interface. This problem is particularly challenging for ankyrin repeat proteins (ARs), which consist of linear arrays of small repeating units and play critical roles in almost every life process via protein-protein interactions, because the residues involved are discontinuously dispersed in both the ARs and their partners… CONTINUE READING

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