Dissection of porphyrin-induced conformational dynamics in the heme biosynthesis enzyme ferrochelatase.

Abstract

Human ferrochelatase (EC 4.99.1.1) catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis, an essential process to most organisms given the vast intracellular functions of heme. Even with multiple ferrochelatase structures available, the exact mechanism for iron insertion into porphyrin is still a matter for debate… (More)

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@article{Asuru2012DissectionOP, title={Dissection of porphyrin-induced conformational dynamics in the heme biosynthesis enzyme ferrochelatase.}, author={Awuri P Asuru and Mier An and Laura S. Busenlehner}, journal={Biochemistry}, year={2012}, volume={51 36}, pages={7116-27} }