Dissection of mechanistic principles of a secondary multidrug efflux protein.

  title={Dissection of mechanistic principles of a secondary multidrug efflux protein.},
  author={Nir Fluman and Christopher M Ryan and Julian P Whitelegge and Eitan Bibi},
  journal={Molecular cell},
  volume={47 5},
Multidrug transporters are ubiquitous efflux pumps that provide cells with defense against various toxic compounds. In bacteria, which typically harbor numerous multidrug transporter genes, the majority function as secondary multidrug/proton antiporters. Proton-coupled secondary transport is a fundamental process that is not fully understood, largely owing to the obscure nature of proton-transporter interactions. Here we analyzed the substrate/proton coupling mechanism in MdfA, a model… CONTINUE READING
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