Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 2: response to ovine corticotropin-releasing factor and naloxone.

@article{Adinoff2005DissectionOH,
  title={Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 2: response to ovine corticotropin-releasing factor and naloxone.},
  author={Bryon Adinoff and Steven R Krebaum and Patricia A. Chandler and Wen Ye and Morton B. Brown and M John M Williams},
  journal={Alcoholism, clinical and experimental research},
  year={2005},
  volume={29 4},
  pages={528-37}
}
BACKGROUND Pituitary and adrenal responsiveness is suppressed in abstinent alcohol-dependent individuals. To clarify the specific organizational disruption in hypothalamic-pituitary-adrenal functioning during early abstinence, the authors separately assessed each level of the stress-response axis. In this second of a two-part study, ovine corticotropin-releasing factor (oCRH) was used to stimulate the pituitary corticotrophs, and naloxone was used to activate the axis at the hypothalamic level… CONTINUE READING