Dissection of double-stranded RNA binding protein B2 from betanodavirus.

@article{Fenner2007DissectionOD,
  title={Dissection of double-stranded RNA binding protein B2 from betanodavirus.},
  author={Beau James Fenner and Winnie Goh and Jimmy Kwang},
  journal={Journal of virology},
  year={2007},
  volume={81 11},
  pages={5449-59}
}
Betanodaviruses are small RNA viruses that infect teleost fish and pose a considerable threat to marine aquaculture production. These viruses possess a small protein, termed B2, which binds to and protects double-stranded RNA. This prevents cleavage of virus-derived double-stranded RNAs (dsRNAs) by Dicer and subsequent production of small interfering RNA (siRNA), which would otherwise induce an RNA-silencing response against the virus. In this work, we have performed charged-to-alanine scanning… CONTINUE READING

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