Dissection of brefeldin A-sensitive and -insensitive steps in apicoplast protein targeting.

  title={Dissection of brefeldin A-sensitive and -insensitive steps in apicoplast protein targeting.},
  author={Amy DeRocher and Brian Gilbert and Jean E. Feagin and Marilyn Parsons},
  journal={Journal of cell science},
  volume={118 Pt 3},
The apicoplast is a relict plastid found in many apicomplexans, including the pathogens Toxoplasma gondii and Plasmodium falciparum. Nucleus-encoded apicoplast proteins enter the ER, and after cleavage of the signal sequence, are routed to the apicoplast by virtue of a transit peptide, which is subsequently removed. To assess the mechanisms of localization we examined stable transfectants of T. gondii for the localization and processing of various GFP fusion proteins. GFP fusions bearing… CONTINUE READING


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A GTP-driven motor moves proteins across the outer envelope of chloroplasts.

Proceedings of the National Academy of Sciences of the United States of America • 2003

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