Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study.

  title={Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study.},
  author={Henrik Amtoft Neubauer and Carsten Gram Hansen and Ove Wiborg},
  journal={Molecular pharmacology},
  volume={69 4},
The serotonin transporter (SERT), which belongs to a family of sodium/chloride-dependent transporters, is the major pharmacological target in the treatment of several clinical disorders, including depression and anxiety. Interaction with a low-affinity allosteric site on SERT modulates the ligand affinity at the high-affinity binding site. Serotonin (5-hydroxytryptamine) and certain SERT inhibitors possess affinity for both sites. In the present study, we report the characterization of a… CONTINUE READING
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