Dissection of amoeboid movement into two mechanically distinct modes.

  title={Dissection of amoeboid movement into two mechanically distinct modes.},
  author={Kunito Yoshida and Thierry Soldati},
  journal={Journal of cell science},
  volume={119 Pt 18},
The current dominant model of cell locomotion proposes that actin polymerization pushes against the membrane at the leading edge producing filopodia and lamellipodia that move the cell forward. Despite its success, this model does not fully explain the complex process of amoeboid motility, such as that occurring during embryogenesis and metastasis. Here, we show that Dictyostelium cells moving in a physiological milieu continuously produce ;blebs' at their leading edges, and demonstrate that… CONTINUE READING
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