Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

@inproceedings{Wallace2015DissectionOA,
  title={Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping},
  author={Chris Wallace and Antony J Cutler and Nikolas Pontikos and Marcin L. Pekalski and Oliver S. Burren and Jason. D Cooper and Arcadio Rubio Garc{\'i}a and Ricardo C Ferreira and Hui Guo and Neil M. Walker and Deborah J. Smyth and Stephen S. Rich and Suna Onengut-Gumuscu and Stephen J Sawcer and Maria Ban and Sylvia Richardson and John A. Todd and Linda S. Wicker and Jonathan Marchini},
  booktitle={PLoS genetics},
  year={2015}
}
Identification of candidate causal variants in regions associated with risk of common diseases is complicated by linkage disequilibrium (LD) and multiple association signals. Nonetheless, accurate maps of these variants are needed, both to fully exploit detailed cell specific chromatin annotation data to highlight disease causal mechanisms and cells, and for design of the functional studies that will ultimately be required to confirm causal mechanisms. We adapted a Bayesian evolutionary… CONTINUE READING