Dissection of TBK 1 signaling via phosphoproteomics in lung cancer cells

@inproceedings{Kima2013DissectionOT,
  title={Dissection of TBK 1 signaling via phosphoproteomics in lung cancer cells},
  author={Jae-Young Kima and Eric A. Welshb and Umut Oguzc and Bin Fangc and Yun Baia and Fumi Kinosea and Crystina Bronkd and Lily L. Remsing Rixe and Amer A. Begd and Uwe Rixe and Steven A. Eschrichb and John M. Koomenf and Eric B. Hauraa},
  year={2013}
}
  • Jae-Young Kima, Eric A. Welshb, +10 authors Eric B. Hauraa
  • Published 2013
TANK-binding kinase 1 (TBK1) has emerged as a novel therapeutic target for unspecified subset of lung cancers. TBK1 reportedly mediates prosurvival signaling by activating NF-κB and AKT. However, we observed that TBK1 knockdown also decreased viability of cells expressing constitutively active NF-κB and interferon regulatory factor 3. Basal phospho-AKT level was not reduced after TBK1 knockdown in TBK1-sensitive lung cancer cells, implicating that TBK1 mediates unknown survival mechanisms. To… CONTINUE READING
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