Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component.

@article{Lambris1996DissectionOC,
  title={Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component.},
  author={John D. Lambris and Zhimin Lao and T J Oglesby and John P Atkinson and C. Erik Hack and J. David Becherer},
  journal={Journal of immunology},
  year={1996},
  volume={156 12},
  pages={4821-32}
}
Previous studies have suggested that the residues 727-768 of human (Hu) C3 contain the binding sites for CR1, factor H, and factor B. Here, we have (1) characterized further some of the C3 structural requirements for its binding to CR1, H, and B, (2) investigated the functions associated with these C3-ligand interactions, and (3) studied the relationship of MCP-binding sites in C3 with those for CR1, H, and B. Hu C3 molecules in which residues 727-768 were deleted (designated C3delta727-768) or… CONTINUE READING

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