Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR

  title={Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR},
  author={Roberto Marcucci and Maurizio Romano and Fabian Feiguin and M. A. O'Connell and Francisco E. Baralle},
  booktitle={Nucleic acids research},
In Drosophila melanogaster, the expression of adenosine deaminase acting on RNA is regulated by transcription and alternative splicing so that at least four different isoforms are generated that have a tissue-specific splicing pattern. Even though dAdar has been extensively studied, the complete adult expression pattern has yet to be elucidated. In the present study, we investigate mature transcripts of dAdar arising from different promoters. Two predominant isoforms of dAdar are expressed in… CONTINUE READING

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