Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.

@article{Li2015DissectingTR,
  title={Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.},
  author={You Qi Li and Daisuke Yamane and Stanley M Lemon},
  journal={Journal of virology},
  year={2015},
  volume={89 9},
  pages={4857-65}
}
UNLABELLED The replication of hepatitis C virus (HCV) is uniquely dependent on a host microRNA, miR-122. Previous studies using genotype 1a H77S.3 virus demonstrated that miR-122 acts in part by protecting the RNA genome from 5' decay mediated by the cytoplasmic 5' exoribonuclease, Xrn1. However, this finding has been challenged by a recent report suggesting that a predominantly nuclear exoribonuclease, Xrn2, mediates the degradation of genotype 2a JFH1 RNA. Here, we dissect the roles of these… CONTINUE READING
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The multifunctional RNase XRN2.

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