Dissecting the role of cadherin-catenin proteins in mammalian epidermis.

I ntercellular adhesion plays a central role in normal metazoan development and homeostasis (1, 2). Cadherin– catenin-mediated adhesion structures are composed of multiple core proteins that may have not only common but also distinct functions. In this issue of PNAS, two studies from the Fuchs laboratory (3, 4) provide interesting novel insights into… CONTINUE READING