Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics

@inproceedings{MendozaParra2011DissectingTR,
  title={Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics},
  author={Marco-Antonio Mendoza-Parra and Mannu Walia and Martial Sankar and Hinrich Gronemeyer},
  booktitle={Molecular systems biology},
  year={2011}
}
Retinoic acid (RA) triggers physiological processes by activating heterodimeric transcription factors (TFs) comprising retinoic acid receptor (RARα, β, γ) and retinoid X receptor (RXRα, β, γ). How a single signal induces highly complex temporally controlled networks that ultimately orchestrate physiological processes is unclear. Using an RA-inducible differentiation model, we defined the temporal changes in the genome-wide binding patterns of RARγ and RXRα and correlated them with transcription… CONTINUE READING