• Corpus ID: 90094859

Dissecting the regulatory roles and cellular functions of mammalian ZSCAN5B and primate-specific paralogs

@inproceedings{Sun2016DissectingTR,
  title={Dissecting the regulatory roles and cellular functions of mammalian ZSCAN5B and primate-specific paralogs},
  author={Younguk Sun},
  year={2016}
}
Particularly in the context of differentiation and development, the importance of three-dimensional chromatin architecture on gene regulation is becoming increasingly clear. The most ancient known mechanism of chromatin organization involves TFIIIC, a transcription factor (TF) that recruits RNA polymerase III (Pol III) for transcription of tRNA and other types of non-coding RNA genes. From yeast to mammals, TFIIIC also binds to scattered “extra-TFIIIC” (ETC) loci, serving to tether those loci… 

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TLDR
The results suggest that human Pol III complexes associate preferentially with regions near functional Pol II promoters and that TFIIIC-mediated recruitment of TFIIIB is regulated in a locus-specific manner.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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