Dissecting the pathological effects of human A 40 and A 42 in Drosophila : A potential model for Alzheimer ’ s disease

@inproceedings{Iijima2004DissectingTP,
  title={Dissecting the pathological effects of human A 40 and A 42 in Drosophila : A potential model for Alzheimer ’ s disease},
  author={Koichi Iijima and H T Liu and Ann-Shyn Chiang and Stephen A. Hearn and Mary Konsolaki and Y Zhong},
  year={2004}
}
Accumulation of amyloid(A ) peptides in the brain has been suggested to be the primary event in sequential progression of Alzheimer’s disease (AD). Here, we use Drosophila to examine whether expression of either the human A 40 or A 42 peptide in the Drosophila brain can induce pathological phenotypes resembling AD. The expression of A 42 led to the formation of diffused amyloid deposits, age-dependent learning defects, and extensive neurodegeneration. In contrast, expression of A 40 caused only… CONTINUE READING