Dissecting the oncogenic and tumorigenic potential of differentiated human induced pluripotent stem cells and human embryonic stem cells.

@article{Ghosh2011DissectingTO,
  title={Dissecting the oncogenic and tumorigenic potential of differentiated human induced pluripotent stem cells and human embryonic stem cells.},
  author={Zhumur Ghosh and Mei Huang and Shijun Hu and Kitchener D. Wilson and Devaveena Dey and Joseph C Wu},
  journal={Cancer research},
  year={2011},
  volume={71 14},
  pages={
          5030-9
        }
}
Pluripotent stem cells, both human embryonic stem cells (hESC) and human-induced pluripotent stem cells (hiPSC), can give rise to multiple cell types and hence have tremendous potential for regenerative therapies. However, the tumorigenic potential of these cells remains a great concern, as reflected in the formation of teratomas by transplanted pluripotent cells. In clinical practice, most pluripotent cells will be differentiated into useful therapeutic cell types such as neuronal, cardiac, or… CONTINUE READING
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