Dissecting the loci of low-level quinine resistance in malaria parasites.

@article{Ferdig2004DissectingTL,
  title={Dissecting the loci of low-level quinine resistance in malaria parasites.},
  author={Michael T. Ferdig and Roland Arthur Cooper and Jianbing Mu and Bingbing Deng and Deirdre A. Joy and Xin-zhuan Su and Thomas E Wellems},
  journal={Molecular microbiology},
  year={2004},
  volume={52 4},
  pages={985-97}
}
Quinine (QN) remains effective against Plasmodium falciparum, but its decreasing efficacy is documented from different continents. Multiple genes are likely to contribute to the evolution of QN resistance. To locate genes contributing to QN response variation, we have searched a P. falciparum genetic cross for quantitative trait loci (QTL). Results identify additive QTL in segments of chromosomes (Chrs) 13, 7 and 5, and pairwise effects from two additional loci of Chrs 9 and 6 that interact… CONTINUE READING
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