Dissecting the insecticide-resistance- associated cytochrome P450 gene Cyp6g1.

@article{McCart2008DissectingTI,
  title={Dissecting the insecticide-resistance- associated cytochrome P450 gene Cyp6g1.},
  author={Caroline McCart and Richard H. ffrench-Constant},
  journal={Pest management science},
  year={2008},
  volume={64 6},
  pages={
          639-45
        }
}
BACKGROUND The cytochrome P450 gene Cyp6g1 is overtranscribed in all field isolates of DDT-resistant Drosophila melanogaster (Meigen) and confers a fitness advantage when inherited via the female. Overtranscription is associated with the insertion of an Accord transposable element into the 5' end of the resistance allele. Here the authors attempt to dissect the transcription of the P450 gene in order to understand why resistance confers an advantage rather than the expected cost. RESULTS… 
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TLDR
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Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross.
Multiple P450s and Variation in Neuronal Genes Underpins the Response to the Insecticide Imidacloprid in a Population of Drosophila melanogaster
TLDR
The genetics of resistance to the neonicotinoid insecticide imidacloprid is explored using the Drosophila Genetic Reference Panel, a collection of inbred Drosophile melanogaster genotypes derived from a single population in North Carolina, and data collectively suggest that imidcloprid resistance is influenced by a variety of previously known and unknown genetic factors.
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TLDR
Microarray analysis of all P450s in Drosophila melanogaster shows that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a single cytochrome P450 gene, Cyp6g1, which has spread globally.
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TLDR
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TLDR
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