Dissecting the insect metabolic machinery using twin ion mass spectrometry: a single P450 enzyme metabolizing the insecticide imidacloprid in vivo.

@article{Hoi2014DissectingTI,
  title={Dissecting the insect metabolic machinery using twin ion mass spectrometry: a single P450 enzyme metabolizing the insecticide imidacloprid in vivo.},
  author={Kin Kuan Hoi and Phillip J. Daborn and Paul Battlay and Charles Robin and Philip J. Batterham and Richard A J O'Hair and W Alexander Donald},
  journal={Analytical chemistry},
  year={2014},
  volume={86 7},
  pages={3525-32}
}
Insecticide resistance is one of the most prevalent examples of anthropogenic genetic change, yet our understanding of metabolic-based resistance remains limited by the analytical challenges associated with rapidly tracking the in vivo metabolites of insecticides at nonlethal doses. Here, using twin ion mass spectrometry analysis of the extracts of whole Drosophila larvae and excreta, we show that (i) eight metabolites of the neonicotinoid insecticide, imidacloprid, can be detected when formed… CONTINUE READING
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