Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells.

@article{Kolben2012DissectingTI,
  title={Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells.},
  author={Thomas Kolben and Iris Per{\"o}bner and Katharina Fernsebner and Felix Lechner and Claudia Geissler and Lourdes Ruiz-Heinrich and Simon Capovilla and Marianne Jochum and Peter Neth},
  journal={Biological chemistry},
  year={2012},
  volume={393 12},
  pages={1433-47}
}
Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high… CONTINUE READING
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