Dissecting the immunobiological effects of Bacillus Calmette-Guérin (BCG) in vitro: evidence of a distinct BCG-activated killer (BAK) cell phenomenon.

@article{Boehle1993DissectingTI,
  title={Dissecting the immunobiological effects of Bacillus Calmette-Gu{\'e}rin (BCG) in vitro: evidence of a distinct BCG-activated killer (BAK) cell phenomenon.},
  author={Andreas Boehle and Andreas Thanh{\"a}user and Artur J. Ulmer and M. D. Ernst and H. D. Flad and Dieter Jocham},
  journal={The Journal of urology},
  year={1993},
  volume={150 6},
  pages={1932-7}
}
Several immunobiological effects of intravesical bacillus Calmette-Guérin (BCG) during immunotherapy of superficial bladder cancer have been suggested as possible mediators of the mode of action. In an attempt to elucidate which of these effects is relevant to tumoricidal activity, an in vitro cytotoxicity assay was employed in which the direct effects of BCG and of cytokines against four transitional carcinoma cell lines were studied. Furthermore, peripheral blood mononuclear cells (PBMNC… CONTINUE READING

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