Dissecting the heterogeneity of rheumatoid arthritis through linkage analysis of quantitative traits.

Abstract

OBJECTIVE To dissect the heterogeneity of rheumatoid arthritis (RA) through linkage analysis of quantitative traits, specifically, IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide (anti-CCP) autoantibody titers. METHODS Subjects, 1,002 RA patients from 491 multiplex families recruited by the North American RA Consortium, were typed for… (More)

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