Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination

@inproceedings{Tete2016DissectingTH,
  title={Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination},
  author={Sarah M Tete and Florian Krammer and Sarah Lartey and Geir Bredholt and John D. Wood and Steinar Skrede and Rebecca Jane Cox},
  booktitle={npj Vaccines},
  year={2016}
}
Traditionally, neutralising antibodies that are directed to the major surface glycoprotein hemagglutinin (HA) head domain are measured as surrogate correlates of protection against influenza. In addition to neutralization, hemagglutinin-specific antibodies may provide protection by mediating antibody-dependent cellular cytotoxicity (ADCC). During the 2009 pandemic, vaccination induced HA-specific antibodies that were mostly directed to the conserved HA stalk domain. However, the protective role… CONTINUE READING
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