Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†

@inproceedings{Kirsten2015DissectingTG,
  title={Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†},
  author={Holger Kirsten and Hoor K. Al-Hasani and Lesca Miriam Holdt and Arnd Gross and Frank Beutner and Knut Krohn and Katrin Horn and Peter Ahnert and Ralph Burkhardt and Kristin Reiche and J{\"o}rg Hackerm{\"u}ller and Markus L{\"o}ffler and Daniel Teupser and Joachim Thiery and Markus Scholz},
  booktitle={Human molecular genetics},
  year={2015}
}
Genetics of gene expression (eQTLs or expression QTLs) has proved an indispensable tool for understanding biological pathways and pathomechanisms of trait-associated SNPs. However, power of most genome-wide eQTL studies is still limited. We performed a large eQTL study in peripheral blood mononuclear cells of 2112 individuals increasing the power to detect trans-effects genome-wide. Going beyond univariate SNP-transcript associations, we analyse relations of eQTLs to biological pathways… CONTINUE READING
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