Dissecting the functional specificities of two Hox proteins.

@article{Joshi2010DissectingTF,
  title={Dissecting the functional specificities of two Hox proteins.},
  author={R. Joshi and Liping Sun and R. Mann},
  journal={Genes \& development},
  year={2010},
  volume={24 14},
  pages={
          1533-45
        }
}
Hox proteins frequently select and regulate their specific target genes with the help of cofactors like Extradenticle (Exd) and Homothorax (Hth). For the Drosophila Hox protein Sex combs reduced (Scr), Exd has been shown to position a normally unstructured portion of Scr so that two basic amino acid side chains can insert into the minor groove of an Scr-specific DNA-binding site. Here we provide evidence that another Drosophila Hox protein, Deformed (Dfd), uses a very similar mechanism to… Expand
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