Dissecting the energetics of a protein-protein interaction: the binding of ovomucoid third domain to elastase.

@article{Baker1997DissectingTE,
  title={Dissecting the energetics of a protein-protein interaction: the binding of ovomucoid third domain to elastase.},
  author={Brian M. Baker and Kenneth P. Murphy},
  journal={Journal of molecular biology},
  year={1997},
  volume={268 2},
  pages={557-69}
}
An understanding of the structural basis for protein-protein interactions, and molecular recognition in general, requires complete characterization of binding energetics. Not only does this include quantification of the changes that occur in all of the thermodynamic parameters upon binding, including the enthalpy, entropy and heat capacity, but a description of how these changes are modulated by environmental conditions, most notably pH. Here, we have investigated the binding of turkey… CONTINUE READING

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