Dissecting the effects of antibiotics on horizontal gene transfer: Analysis suggests a critical role of selection dynamics.

@article{Lopatkin2016DissectingTE,
  title={Dissecting the effects of antibiotics on horizontal gene transfer: Analysis suggests a critical role of selection dynamics.},
  author={Allison J. Lopatkin and Tatyana A. Sysoeva and L. You},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2016},
  volume={38 12},
  pages={
          1283-1292
        }
}
Horizontal gene transfer (HGT) is a major mechanism responsible for the spread of antibiotic resistance. Conversely, it is often assumed that antibiotics promote HGT. Careful dissection of the literature, however, suggests a lack of conclusive evidence supporting this notion in general. This is largely due to the lack of well-defined quantitative experiments to address this question in an unambiguous manner. In this review, we discuss the extent to which HGT is responsible for the spread of… Expand
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