Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis.

@article{Nickdel2009DissectingTC,
  title={Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis.},
  author={Mohammad B Nickdel and Paola Conigliaro and Guido Valesini and Sharon Hutchison and R. Benson and Robert V Bundick and Andrew J. Leishman and Iain B. Mcinnes and James M Brewer and Paul G Garside},
  journal={Annals of the rheumatic diseases},
  year={2009},
  volume={68 6},
  pages={1059-66}
}
BACKGROUND The relative roles of innate immunity and antigen-specific T cells in rheumatoid arthritis remain controversial. Previous studies demonstrated that T-helper type 1 cells of irrelevant antigen specificity (ovalbumin) induced a transient arthritis in BALB/c mice, which recapitulates many of the pre-articular and articular features of human disease and is associated with the emergence of autoreactive T and B-cell responses to joint-specific antigens. However, the mechanisms underlying… CONTINUE READING

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