Dissecting the centromere of the human Y chromosome with cloned telomeric DNA.

@article{Brown1994DissectingTC,
  title={Dissecting the centromere of the human Y chromosome with cloned telomeric DNA.},
  author={Karin Elliott Brown and Michael A. Barnett and Carola Burgtorf and Peter Shaw and Veronica J. Buckle and William R. A. Brown},
  journal={Human molecular genetics},
  year={1994},
  volume={3 8},
  pages={1227-37}
}
We have used telomeric DNA to break the human Y chromosome within the centromeric array of alphoid satellite DNA and have created two derivative chromosomes; one consists of the short arm and 140 kb of alphoid DNA, the other consists of the long arm and 480 kb of alphoid DNA. Both segregate accurately at mitosis. It is known that there is no large scale sequence duplication around the alphoid DNA and so the simplest interpretation of our results is that the sequence responsible for accurate… CONTINUE READING

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