Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes–Amazonia Divide

@article{GnecchiRuscone2019DissectingTP,
  title={Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes–Amazonia Divide},
  author={Guido Alberto Gnecchi-Ruscone and Stefania Sarno and Sara De Fanti and Laura Gianvincenzo and Cristina Giuliani and Alessio Boattini and Eugenio Bortolini and Tullia Di Corcia and Cesar Sanchez Mellado and Taylor Jesus D{\`a}vila Francia and Davide Gentilini and Anna Maria di Blasio and Patrizia Di Cosimo and Elisabetta Cilli and Antonio Gonz{\'a}lez-Mart{\'i}n and Claudio Franceschi and Zelda Alice Franceschi and Olga Rickards and Marco Sazzini and Donata Luiselli and Davide Pettener},
  journal={Molecular Biology and Evolution},
  year={2019},
  volume={36},
  pages={1254 - 1269}
}
Extensive European and African admixture coupled with loss of Amerindian lineages makes the reconstruction of pre-Columbian history of Native Americans based on present-day genomes extremely challenging. [...] Key Method To this end, we generated new high-resolution genome-wide data for 229 individuals representative of one Central and ten South Amerindian ethnic groups from Mexico, Peru, Bolivia, and Argentina.Expand
Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
TLDR
New high-throughput genotyping data for 87 admixed individuals across Argentina is presented and confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and evidence is provided for the presence of Northern European and Eastern African ancestries.
Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
TLDR
Genotyping data for 87 admixed individuals throughout Argentina was generated and data from the literature was re-analyzed to shed light on the origins of these three continental ancestry components in Argentinean populations nowadays.
Genomic insights into the early peopling of the Caribbean
TLDR
Genome-wide data for 93 ancient Caribbean islanders reveals evidence of at least three separate dispersal events into the region, including two early dispersals into the Western Caribbean, one of which seems connected to radiation events in North America.
Archaeogenomic Distinctiveness of the Isthmo-Colombian Area
TLDR
The authors' analyses reveal that pre-Hispanic demographic changes and isolation events contributed to create the extensive genetic structure currently seen in the area, which is also characterized by a distinctive Isthmo-Colombian Indigenous component.
The Ancestry of Eastern Paraguay: A Typical South American Profile with a Unique Pattern of Admixture
Immigrants from diverse origins have arrived in Paraguay and produced important demographic changes in a territory initially inhabited by indigenous Guarani. Few studies have been performed to
A Paleogenomic Reconstruction of the Deep Population History of the Andes
Summary There are many unanswered questions about the population history of the Central and South Central Andes, particularly regarding the impact of large-scale societies, such as the Moche, Wari,
Uniparental Lineages from the Oldest Indigenous Population of Ecuador: The Tsachilas
TLDR
The results indicated a possible common origin between the Tsachilas, the Chachi, and other Ecuadorian and Colombian Barbacoans and are suggestive of an interesting ancient linkage to the Inca invaders in Yumbo country.
Genetic assessment reveals no population substructure and divergent regional and sex-specific histories in the Chachapoyas from northeast Peru
TLDR
High genetic diversity is observed in the Chachapoyas, despite the documented dramatic population declines, and genetic markers show no significant evidence for past or current population substructure, although an Amazonian gene flow dynamic in the northern part of this territory is suggested.
The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture.
  • V. Borda, Isabela Alvim, +25 authors H. Guio
  • Medicine, Geography
    Proceedings of the National Academy of Sciences of the United States of America
  • 2020
TLDR
Genetic data from 18 Peruvian populations reveal the between-population homogenization of the central southern Andes and its differentiation with respect to Amazonian populations of similar latitudes do not extend northward, and longitudinal gene flow between the northern coast of Peru, Andes, and Amazonia accompanied cultural and socioeconomic interactions revealed by archeology.
Genomic insight into the origins and dispersal of the Brazilian coastal natives
TLDR
It is demonstrated that the Tupiniquim Native American ancestry is not related to any extant Brazilian Native American population already studied, and thus they could be considered the only living representatives of the extinct Tupí branch that used to settle the Atlantic Coast of Brazil.
...
1
2
...

References

SHOWING 1-10 OF 78 REFERENCES
Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire
TLDR
It is found that the Native American populations possess distinct ancestral divisions, whereas the mestizo groups were admixtures of multiple Native American communities that occurred before and during the Inca Empire and Spanish rule.
Reconstructing Native American Migrations from Whole-Genome and Whole-Exome Data
TLDR
The genomic contributions of African, European, and especially Native American ancestry to these populations are explored and identity-by-descent (IBD) and ancestry tract length are compared to find evidence for relatedness among European founders to the three populations.
Genomic Insights into the Ancestry and Demographic History of South America
TLDR
A strong gradient in the Native American ancestry component of South American Latinos associated with country of origin and the geography of local indigenous populations is found, which can impact the understanding of population-level differences in biomedical traits and, thus, inform future medical genetic studies in the region.
A genomic view of the peopling of the Americas.
TLDR
It is shown that during the Holocene, new migrations from Asia introduced the Saqqaq/Dorset Paleoeskimo population to the North American Arctic ∼4500 years ago, ancestry that is potentially connected with ancestry found in Athabaskan-speakers today.
Reconstructing the Population Genetic History of the Caribbean
TLDR
It is demonstrated that the ancestral components in admixed genomes can be traced back to distinct sub-continental source populations with far greater resolution than previously thought, even when limited pre-Columbian Caribbean haplotypes have survived.
Reconstructing Native American Population History
TLDR
It is shown that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America.
Mitochondrial population genomics supports a single pre-Clovis origin with a coastal route for the peopling of the Americas.
TLDR
It is shown, by using 86 complete mitochondrial genomes, that all Native American haplogroups, including haplogroup X, were part of a single founding population, thereby refuting multiple-migration models and supporting a pre-Clovis occupation of the New World.
Early human dispersals within the Americas
TLDR
Analysis of the oldest genomes suggests that there was an early split within Beringian populations, giving rise to the Northern and Southern lineages, and that the early population spread widely and rapidly suggests that their access to large portions of the hemisphere was essentially unrestricted, yet there are genomic and archaeological hints of an earlier human presence.
The peopling of South America and the trans-Andean gene flow of the first settlers.
TLDR
The data reveal that the Peruvian Altiplano was an important enclave for early Paleoindian expansions and point to a genetic continuity in the Andes until recent times, which was only marginally affected by gene flow from the Amazonian lowlands.
Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
TLDR
It is shown that ancestry-positive assortative mating permeated Brazilian history and shows that continental admixture rather than local post-Columbian history is the main and complex determinant of the individual amount of deleterious genotypes.
...
1
2
3
4
5
...