Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes

@inproceedings{Wuttke2012DissectingTG,
  title={Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes},
  author={Daniel Wuttke and Richard Connor and Chintan Vora and Thomas Craig and Yang Li and Shona H. Wood and Olga Vasieva and Robert J Shmookler Reis and Fusheng Tang and Jo{\~a}o Pedro de Magalh{\~a}es},
  booktitle={PLoS genetics},
  year={2012}
}
Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition, delays the aging process and extends lifespan in multiple organisms. The conserved life-extending effect of DR suggests the involvement of fundamental mechanisms, although these remain a subject of debate. To help decipher the life-extending mechanisms of DR, we first compiled a list of genes that if genetically altered disrupt or prevent the life-extending effects of DR. We called these DR-essential… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 10 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 116 references

A metaanalysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms

M Plank, D Wuttke, S van Dam, SA Clarke, JP de Magalhaes
Mol Biosyst • 2012
View 4 Excerpts
Highly Influenced

Using the reactome database.

Current protocols in bioinformatics • 2012
View 2 Excerpts
Highly Influenced

CORUM: the comprehensive resource of mammalian protein complexes--2009.

Nucleic acids research • 2010
View 2 Excerpts
Highly Influenced

Predicting genetic modifier loci using functional gene networks.

Genome research • 2010
View 2 Excerpts
Highly Influenced

Induction of autophagy by spermidine promotes longevity

Nature Cell Biology • 2009
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…