Dissecting the Conformational Dynamics-Modulated Enzyme Catalysis with Single-Molecule FRET.

@article{Wu2018DissectingTC,
  title={Dissecting the Conformational Dynamics-Modulated Enzyme Catalysis with Single-Molecule FRET.},
  author={Shaowen Wu and Jianwei Liu and Wenning Wang},
  journal={The journal of physical chemistry. B},
  year={2018},
  volume={122 23},
  pages={
          6179-6187
        }
}
Conformational changes of enzyme proteins are often coupled with a catalytic reaction and modulate the enzyme activity. Single-molecule technology is a powerful tool to study the mechanism of enzyme catalysis in these complicated cases. However, the chemical reaction cycles and conformational changes could not be monitored simultaneously in a single… CONTINUE READING