Dissecting the Chemistry of Protein Splicing and Its Applications.

  title={Dissecting the Chemistry of Protein Splicing and Its Applications.},
  author={Nor{\'e}n and Z B Wang and Perler},
  journal={Angewandte Chemie},
  volume={39 3},
Protein splicing, the protein equivalent of RNA splicing, is a newly discovered posttranslational process that proceeds through a branched protein intermediate and produces two separate polypeptides from one gene. The experimental data used to distinguish among the proposed protein-splicing mechanisms are presented along with the progress made towards fully describing the mechanism. Numerous protein engineering applications using modified inteins have been developed, including the generation of… CONTINUE READING

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