Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.

@article{Molinolo2007DissectingTA,
  title={Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.},
  author={Alfredo A Molinolo and Stephen M. Hewitt and Panomwat Amornphimoltham and S Keelawat and Samraeung Rangdaeng and Abelardo Meneses Garc{\'i}a and Ana Rosa Raimondi and Rafael Jufe and Mar{\'i}a Elina Itoiz and Yan Gao and Dhananjaya Saranath and George S Kaleebi and George H. Yoo and Lee V. Leak and Ernest M Myers and Satoru Shintani and David Wong and Hugh Davis Massey and W A Yeudall and Fulvio Lonardo and John Ensley and J. Silvio Gutkind},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 17},
  pages={4964-73}
}
PURPOSE As an approach to evaluate the expression pattern and status of activation of signaling pathways in clinical specimens from head and neck squamous cell carcinoma (HNSCC) patients, we established the Head and Neck Cancer Tissue Array Initiative, an international consortium aimed at developing a high-density HNSCC tissue microarray, with a high representation of oral squamous cell carcinoma. EXPERIMENTAL DESIGN These tissue arrays were constructed by acquiring cylindrical biopsies from… CONTINUE READING

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