Dissecting specific and global transcriptional regulation of bacterial gene expression

@inproceedings{Gerosa2013DissectingSA,
  title={Dissecting specific and global transcriptional regulation of bacterial gene expression},
  author={Luca Gerosa and Karl Kochanowski and Matthias Heinemann and Uwe Sauer},
  booktitle={Molecular systems biology},
  year={2013}
}
Gene expression is regulated by specific transcriptional circuits but also by the global expression machinery as a function of growth. Simultaneous specific and global regulation thus constitutes an additional--but often neglected--layer of complexity in gene expression. Here, we develop an experimental-computational approach to dissect specific and global regulation in the bacterium Escherichia coli. By using fluorescent promoter reporters, we show that global regulation is growth rate… CONTINUE READING
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