Dissecting polysialic acid and NCAM functions in brain development.

  title={Dissecting polysialic acid and NCAM functions in brain development.},
  author={Herbert Hildebrandt and Martina M{\"u}hlenhoff and Birgit Weinhold and Rita Gerardy-Schahn},
  journal={Journal of neurochemistry},
  volume={103 Suppl 1},
The unique modification of the neural cell adhesion molecule (NCAM) by polysialic acid (polySia) is tightly associated with nervous system development and plasticity. The prevailing view that this large carbohydrate polymer acts as an anti-adhesive factor seems straightforward at first sight. However, during almost 25 years of polySia research it became increasingly clear that the impact of polySia on cell surface interactions can not be explained by one unifying mechanism. Recent progress in… CONTINUE READING
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